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San Francisco holds a slim 10-9 edge in its all-time series with Pittsburgh, with the Steelers closing the gap with a 37-16 home rout when these teams last met in 2007. The 49ers had taken four of the previous five bouts in the set prior to that loss, including a 30-14 verdict at Candlestick Park in 2003. The Steelers last won in San Francisco on Nov. 7, 1999, a 27-6 victory.

WHEN THE STEELERS HAVE THE BALL

Another reason why the Steelers may not want to go run-heavy is the strength of San Francisco's sturdy defense in that department. The 49ers have limited the opposition to a league-lows of 70.5 rushing yards per game and 3.2 yards per carry and have yet to give up a touchdown on the ground this season, while the team's string of 35 consecutive contests without permitting an individual 100- yard rusher is the third-longest in the NFL since 2000. The unit may not have its best stopper on Monday, though, with All-Pro inside linebacker Patrick Willis (93 tackles, 2 sacks, 1 INT) highly questionable with a hamstring strain that kept him out of last week's loss as well. The Niners were still able to hold Arizona to a mere 55 rushing yards on 23 totes with him out, with emerging star linebacker NaVorro Bowman (113 tackles) and rugged lineman Justin Smith (47 tackles, 6.5 sacks) leading the charge. Skelton came up with 282 passing yards and three touchdowns off the bench, however, with two of those scoring deliveries from 46 yards out or more. The secondary does contain two members with five interceptions each this year in cornerback Carlos Rogers (35 tackles, 15 PD) and free safety Dashon Goldson (54 tackles), while impressive rookie Aldon Smith (27 tackles, 10.5 sacks) and Ahmad Brooks (39 tackles, 6 sacks) offer two quality edge rushers from the outside linebacker positions.

San Francisco generally employs a conservative, ball-control philosophy that's been highly effective when workhorse running back Frank Gore (1054 rushing yards, 6 TD, 16 receptions) is at his best. That was certainly the case when the hard-nosed veteran ripped off five consecutive 100-yard games during a midseason tear, but he's been less of a factor down the stretch while fighting through some nagging injuries. The 49ers still sit seventh in the NFL in rushing offense (126.9 ypg) and have a league-low 10 giveaways on the year, with cerebral quarterback Alex Smith (2565 passing yards, 15 TD, 5 INT) having a fine season in what's been essentially a caretaker's role. There are some issues to sort out for the playoffs, though. San Francisco is at the bottom of the standings in red-zone execution, having produced touchdowns on an unwanted 35.6 percent of such drives, and Smith has been sacked 18 times over the past three weeks after being taken to the turf on five occasions by the Cardinals. The former No. 1 overall pick may be without his blind-side protector on Monday as well, with left tackle Joe Staley questionable after sustaining a concussion against Arizona. San Francisco doesn't throw the ball a whole lot, but young wide receiver Michael Crabtree (55 receptions, 2 TD) and athletic tight end Vernon Davis (49 receptions, 5 TD) have both been reliable targets for Smith.

Without question, what will transpire at the quarterback position for Pittsburgh will have a big impact on the outcome of this game. Though Batch is serviceable and experienced, it would be a stretch to believe he'll be able to slice through a top-tier defense like San Francisco's without a hitch, and it's a must that the Steelers mount some semblance of a passing threat because the 49ers are so good against the run. Even at far less than 100 percent, Roethlisberger gives his team its best chance of winning, though Pittsburgh's explosiveness on offense may be reduced if his arm strength is affected by the injury.

Pittsburgh is going to have to rely on its defense whether or not Roethlisberger suits up, and how the AFC powerhouses perform on that side of the ball is often an indicator of their success. The Steelers are 9-0 when giving up 306 total yards or less this season, and the 49ers average only a shade above that number on offense for the year.

OVERALL ANALYSIS

Sportsbook Betting Lines Predicted Outcome: Steelers 20, 49ers 16

Knox was taken off the field on a stretcher after taking a hard hit during Sunday's game against the Seattle Seahawks.

Seattle defensive lineman Anthony Hargrove came flying in and hit Knox up high. The wide receiver's head snapped back due to the force of the hit.

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